I think your question needs to be broken down in order to properly answer it.

Can we achieve 3D animation in a 2D animation software? well, the obvious answer is of course no. You can't fit a 3D model in a 2D space.

Perhaps though you meant to ask something different, like "Can we achieve a complete character turnaround in Spine?" to which I can happily answer yes, as I tried various turnaround styles, which you can see/download here: Spine: Twitch: video 7 xPu1y Sp8
They require a bit of work but they're totally doable.
Different poses are also possible within the same skeleton. I think planning your character ahead is the best way to know how many pieces you will need.

This kind of questions gets asked every now and then, so I'll link to a couple of answers I already gave in other threads:
Best way to do "Back" and "Front" on the same character.
Animating isometric character, recommendations

I hope this is what you wanted to know, if not and you could clarify I'd be happy to answer your doubts